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The other sweet face of XBP-1

Nature Medicine volume 17, pages 246–248 (2011)Cite this article

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X-box–binding protein-1 (XBP-1) increases insulin sensitivity by activating endoplasmic reticulum capacity during feeding to control glucose homeostasis, a function severely impaired in obesity. But XBP-1 can also increase glucose tolerance in obese and diabetic mice by blocking gluconeogenesis, independent of its effect on insulin sensitivity, opening new avenues for type 2 diabetes therapies (pages 356–365).

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Figure 1: A dual mechanistic role for XBP-1 in improving glucose homeostasis.

Katie Vicari

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Authors and Affiliations

  1. Kohjiro Ueki and Takashi Kadowaki are in the Department of Diabetes and Metabolic Disease, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.,

    Kohjiro Ueki & Takashi Kadowaki

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  1. Kohjiro Ueki
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  2. Takashi Kadowaki
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Correspondence to Kohjiro Ueki.

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Ueki, K., Kadowaki, T. The other sweet face of XBP-1. Nat Med 17, 246–248 (2011). https://doi.org/10.1038/nm0311-246

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