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Kaposi virus scores cancer coup

Kaposi sarcoma herpesvirus (KSHV) seems to exploit almost every known cancer pathway to promote tumorigenesis. Activation of the canonical Wnt–β-catenin pathway can now be added to its list of conquests (pages 300–306).

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Figure 1: KSHV activates the Wnt-β-catenin pathway.

Kimberly Homer

References

  1. Chang, Y. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865–1869 (1994).

    Article  CAS  PubMed  Google Scholar 

  2. Boshoff, C. & Weiss, R.A. AIDS-related malignancies. Nat. Rev. Cancer 2, 373–382 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Fujimuro, M. et al. A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 9, 300–306 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837–1851 (2000).

    CAS  PubMed  Google Scholar 

  5. Kielman, M.F. et al. Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling. Nat. Genet. 32, 594–605 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Ballestas, M.E., Chatis, P.A. & Kaye, K.M. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284, 641–644 (1999).

    Article  CAS  PubMed  Google Scholar 

  7. Friborg, J., Kong, W., Hottiger, M.O. & Nabel, G.J. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402, 889–894 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Radkov, S.A., Kellam, P. & Boshoff, C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 6, 1121–1127 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Verschuren, E.W., Klefstrom, J., Evan, G.I. & Jones, N. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell 2, 229–241 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Bais, C. et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 391, 86–89 (1998).

    Article  CAS  PubMed  Google Scholar 

  11. Montaner, S. et al. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3, 23–36 (2002).

    Article  Google Scholar 

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Boshoff, C. Kaposi virus scores cancer coup. Nat Med 9, 261–262 (2003). https://doi.org/10.1038/nm0303-261

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