Kaposi sarcoma herpesvirus (KSHV) seems to exploit almost every known cancer pathway to promote tumorigenesis. Activation of the canonical Wnt–β-catenin pathway can now be added to its list of conquests (pages 300–306).
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References
Chang, Y. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865–1869 (1994).
Boshoff, C. & Weiss, R.A. AIDS-related malignancies. Nat. Rev. Cancer 2, 373–382 (2002).
Fujimuro, M. et al. A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 9, 300–306 (2003).
Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837–1851 (2000).
Kielman, M.F. et al. Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling. Nat. Genet. 32, 594–605 (2002).
Ballestas, M.E., Chatis, P.A. & Kaye, K.M. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284, 641–644 (1999).
Friborg, J., Kong, W., Hottiger, M.O. & Nabel, G.J. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402, 889–894 (1999).
Radkov, S.A., Kellam, P. & Boshoff, C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 6, 1121–1127 (2000).
Verschuren, E.W., Klefstrom, J., Evan, G.I. & Jones, N. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell 2, 229–241 (2002).
Bais, C. et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 391, 86–89 (1998).
Montaner, S. et al. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3, 23–36 (2002).
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Boshoff, C. Kaposi virus scores cancer coup. Nat Med 9, 261–262 (2003). https://doi.org/10.1038/nm0303-261
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DOI: https://doi.org/10.1038/nm0303-261
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