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Liver transplants contribute to their own success

Nature Medicine volume 2, pages 163–165 (1996)Cite this article

Stowaway stem cells in liver contribute to immunological tolerance in patients receiving liver transplants (pages 198–203).

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References

  1. Taniguchi, H., Toyoshima, T., Fukao K. & Nakauchi, H. Presence of hematopoietic stem cells in the adult liver. Nature Med. 2, 198–203 (1996).

    Article  CAS  Google Scholar 

  2. Murase, N. et al. Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation: With particular reference to the liver. Transplantation 61, 1–3 (1996).

    Article  CAS  Google Scholar 

  3. Hays, E.F., Hays, D.M. & Golde, D.W. Hemopoietic stem cells in mouse liver. Exp. Hematol. 6, 18–27 (1978).

    CAS  PubMed  Google Scholar 

  4. Decker, T., Lohmann-Matthes, M.L. & Baccarini, M. Liver-associated macrophage precursor cells proliferate under impairment of regular hemopoiesis. Eur. J. Immunol. 18, 697–703 (1988).

    Article  CAS  Google Scholar 

  5. Starzl, T.E. et al. Cell migration, chimerism, and graft acceptance. Lancet 339, 1579–1582 (1992).

    Article  CAS  Google Scholar 

  6. Starzl, T.E. et al. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance. Hepatology 17, 1127–1152 (1993).

    Article  CAS  Google Scholar 

  7. Demetris, A.J. et al. Hematolymphoid cell trafficking, microchimerism, and GVHD reactions after liver, bone marrow, and heart transplantation. Transplantation Proc. 25, 3337–3344 (1993).

    CAS  Google Scholar 

  8. Qian, S. et al. Murine liver allograft transplantation: ToleranceanddonorCellchimerism. Hepatology 19, 916–924 (1994).

    Article  CAS  Google Scholar 

  9. Przepiorka, D., Thomas, E.D., Durham, D.M. & Fisher, L. Use of a probe to repeat sequence of the Y chromosome for detection of host cells in peripheral blood of bone marrow transplant recipients. Hematopathology 95, 201–206 (1991).

    CAS  Google Scholar 

  10. Billingham, R.E., Brent, L. & Medawar, P.B. “Actively acquired tolerance” of foreign cells. Nature 172, 603–606 (1953).

    Article  CAS  Google Scholar 

  11. Starzl, T.E. et al. Factors determining short-and long-term survival after orthotopic liver homotransplantation in the dog. Surgery 58, 131–155 (1965).

    PubMed  PubMed Central  Google Scholar 

  12. Calne, R.Y. Induction of immunological tolerance by porcine liver allografts. Nature 223, 472–474 (1969).

    Article  CAS  Google Scholar 

  13. Kamada, N., Davies, HffS. & Roser, B. Reversal of transplantationimmunity bylivergrafting. Nature 292, 840–842 (1981).

    Article  CAS  Google Scholar 

  14. Lu, L. et al. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/ macrophage colony-stimulating factor. J. Exp. Med. 182, 379–387 (1995).

    Article  CAS  Google Scholar 

  15. Thomson, A.W. et al. Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells 13, 622–639 (1995).

    Article  CAS  Google Scholar 

  16. Murase, N. et al. Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown-Norway rats. Transplantation 60, 158–171 (1995).

    Article  CAS  Google Scholar 

  17. Davies, HffS., Pollard, S.G. & Calne, R.Y. Soluble HLA antigens in the circulation of liver graft recipients. Transplantation 47, 524–527 (1989).

    Article  CAS  Google Scholar 

  18. Calne, R. & Davies, H. Organ graft tolerance: The liver effect. Lancet 343, 67–68 (1994).

    Article  CAS  Google Scholar 

  19. Steinman, R.M. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunology 9, 271–296 (1991).

    Article  CAS  Google Scholar 

  20. Burlingham, W.J. Microchimerism linked to cytotoxic T lymphocyte functional unresponsive-ness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 59, 1147–1155 (1995).

    Article  CAS  Google Scholar 

  21. Monaco, A.P. et al. Possible active enhancement of human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: Case report of an initial attempt. Surgery 79 384–392 (1976).

    CAS  PubMed  Google Scholar 

  22. Fontes, P. et al. Bone marrow augmentation of donor cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet 344, 151–155 (1994).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Pittsburgh Transplantation Institute, Pittsburgh, Pennsylvania, 15213, USA

    Thomas E. Starzl, Noriko Murase, Angus Thomson & Anthony J. Demetris

Authors
  1. Thomas E. Starzl
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  2. Noriko Murase
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  3. Angus Thomson
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  4. Anthony J. Demetris
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Starzl, T., Murase, N., Thomson, A. et al. Liver transplants contribute to their own success. Nat Med 2, 163–165 (1996). https://doi.org/10.1038/nm0296-163

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