The demonstration that transplanted embryonic stem cells differentiate into functional dopamine neurons and provide stable functional recovery in a rodent model of Parkinson disease moves the field a step closer to clinical applications of embryonic stem cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dunnett, S.B. & Björklund, A. Parkinson's disease: prospects for novel restorative and neuroprotective treatments. Nature 399, S32–S39 (1999).
Dunnett, S.B., Björklund, A. & Lindvall, O. Cell therapy in Parkinson's disease—stop or go? Nature Rev. Neurosci. 2, 365–369 (2001).
Björklund, L. et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA (in the press).
Dunnett, S.B. & Björklund, A. Mechanisms of function of neural grafts in the injured brain. in Functional Neural Transplantation. 531–567 (Raven Press, New York, 1994).
Mezey, E., Chandross, K.J., Harta, G., Maki, R.A. & McKercher, S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779–1782 (2000).
Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M. & McKay, R.D. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nature Biotechnol. 18, 675–679 (2000).
Li, M., Pevny, L., Lovell-Badge, R. & Smith, A. Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr. Biol. 8, 971–974 (1998).
Zhang, S.C., Wernig, M., Duncan, I.D., Brustle, O. & Thomson, J.A. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnol. 19, 1129–1133 (2001).
Reubinoff, B.E. et al. Neural progenitors from human embryonic stem cells. Nature Biotechnol. 19, 1134–1140 (2001).
Deacon, T., Dinsmore, J., Constantini, L. C., Ratliff, J. & Isacson, O. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. Exp. Neurol. 149, 28–41 (1998).
Ling, Z.D., Potter, E.D., Lipton, J.W. & Carvey, P.M. Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Exp. Neurol. 149, 411–423 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fricker-Gates, R., Dunnett, S. Rewiring the Parkinsonian brain. Nat Med 8, 105–106 (2002). https://doi.org/10.1038/nm0202-105
Issue Date:
DOI: https://doi.org/10.1038/nm0202-105