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Neuropathology in the Down's syndrome brain

The presence of a specific amyloid β-protein in the brains of Down's syndrome patients suggests a common etiological pathway with the development of Alzheimer's disease-related neuropathology (pages 93–95).

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References

  1. Teller, J.K. et al. Presence of soluble amyloid β peptide precedes amyloid plaque formation in Down's syndrome. Nature Med. 2, 93–95 (1996).

    Article  CAS  Google Scholar 

  2. Hilbich, C. et al. Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J. Mol.Biol. 218, 149–163 (1991).

    Article  CAS  Google Scholar 

  3. Jarrett, J.T., Berger, E.P. & Lansbury, P.T. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32, 4693–4697 (1993).

    Article  CAS  Google Scholar 

  4. Gravina, S.A. et al. Amyloid β protein (A β) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms of A β 40 and A β 42(43). J. Biol. Chem. 270, 7013–7016 (1995).

    Article  CAS  Google Scholar 

  5. Iwatsubo, T., Mann, D.M., Odaka, A., Suzuki, N. & Ihara, Y. Amyloid β protein (A β) deposition: A β 42(43) precedes A β 40 in Down Syndrome. Ann. Neural. 37, 294–299 (1995).

    Article  CAS  Google Scholar 

  6. Suzuki, N. et al. An increased percentage of long amyloid β protein secreted by familial amyloid b protein precursor (bAPP717) mutants. Science 264, 1336–1340 (1994).

    Article  CAS  Google Scholar 

  7. Sherrington, R. et al. Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease. Nature 375, 754–760 (1995).

    Article  CAS  Google Scholar 

  8. Levy-Lahad, E. et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973–977 (1995).

    Article  CAS  Google Scholar 

  9. Kang, J. et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733–736 (1987).

    Article  CAS  Google Scholar 

  10. Tanzi, R.E. et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880–884 (1987).

    Article  CAS  Google Scholar 

  11. Mann, D.M., Younis, N., Jones, D. & Stoddart, R.W. The time course of pathological events in Down's syndrome with particular reference to the involvement of microglial cells and deposits of β/A4. Neurodegeneration 1, 201–215 (1992).

    Google Scholar 

Download references

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Tanzi, R. Neuropathology in the Down's syndrome brain. Nat Med 2, 31–32 (1996). https://doi.org/10.1038/nm0196-31

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