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Reply to: "Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development" and "Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis"

Nature Medicine volume 17, pages 27–29 (2011)Cite this article

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Saito et al. reply:

As Araldi et al.1 mention in their correspondence, our previous article describes that mice heterozygous for knockout of the gene encoding hypoxia-inducible factor-2α (Epas1+/− mice) show mild and transient impairment in endochondral ossification during skeletal growth mainly in the embryonic stage2. We disagree with their hypothesis that there would be marked impairment due to homozygous deficiency of the gene, as the amount of HIF-2α essential for the maintenance of normal skeletal growth is unknown. Therefore, we are interested in their findings in more sophisticated mouse mutants with homozygous deficiency of Epas1 in limb bud mesenchyme, achieved by tissue-selective knockout.

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References

  1. Araldi, E. et al. Nat. Med. 17, 25–26 (2011).

    Article  CAS  Google Scholar 

  2. Saito, T. et al. Nat. Med. 16, 678–686 (2010).

    Article  CAS  Google Scholar 

  3. Patel, S.A. & Simon, M.C. Cell Death Differ. 15, 628–634 (2008).

    Article  CAS  Google Scholar 

  4. Scortegagna, M. et al. Nat. Genet. 35, 331–340 (2003).

    Article  CAS  Google Scholar 

  5. Schipani, E. et al. Genes Dev. 15, 2865–2876 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Nakajima, M. et al. Nat. Med. 17, 26–27 (2011).

    Article  CAS  Google Scholar 

  7. Spector, T.D. et al. Osteoarthritis Cartilage 12, S39–S44 (2004).

    Article  Google Scholar 

  8. Muraki, S. et al. Osteoarthritis Cartilage 17, 1137–1143 (2009).

    Article  CAS  Google Scholar 

  9. Miyamoto, Y. et al. Nat. Genet. 39, 529–533 (2007).

    Article  CAS  Google Scholar 

  10. Nakajima, M. et al. PLoS ONE 5, e9723 (2010).

    Article  Google Scholar 

  11. Shi, D., et al. Osteoarthritis Cartilage 18, 1454–1457 (2010).

    Article  CAS  Google Scholar 

  12. Mabuchi, A. et al. J. Hum. Genet. 46, 456–462 (2001).

    Article  CAS  Google Scholar 

  13. Ikeda, T. et al. J. Hum. Genet. 46, 538–543 (2001).

    Article  CAS  Google Scholar 

  14. Kizawa, H. et al. Nat. Genet. 37, 138–144 (2005).

    Article  CAS  Google Scholar 

  15. Mototani, H. et al. Hum. Mol. Genet. 14, 1009–1017 (2005).

    Article  CAS  Google Scholar 

  16. Kerkhof H.J. et al. Osteoarthritis Cartilage published online, 10.1016/j.joca.2010.10.027 (6 November 2010).

    Google Scholar 

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Authors and Affiliations

  1. Sensory & Motor System Medicine, Hongo, Bunkyo-ku, Tokyo, Japan

    Taku Saito, Toru Akune, Ung-il Chung & Hiroshi Kawaguchi

  2. Human Genetics, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan

    Akihiko Mabuchi & Katsushi Tokunaga

Authors
  1. Taku Saito
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Correspondence to Hiroshi Kawaguchi.

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Saito, T., Mabuchi, A., Akune, T. et al. Reply to: "Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development" and "Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis". Nat Med 17, 27–29 (2011). https://doi.org/10.1038/nm0111-27

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