The neuronal accumulation of mutant huntingtin is a hallmark of Huntington's disease. New research shows that post-translational modifications of the mutant protein promote its clearance, uncovering new therapeutic targets for this disorder.
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Krainc, D. Huntington's disease: tagged for clearance. Nat Med 16, 32–33 (2010). https://doi.org/10.1038/nm0110-32
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DOI: https://doi.org/10.1038/nm0110-32
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Glycation potentiates neurodegeneration in models of Huntington’s disease
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