Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Huntington's disease: tagged for clearance

The neuronal accumulation of mutant huntingtin is a hallmark of Huntington's disease. New research shows that post-translational modifications of the mutant protein promote its clearance, uncovering new therapeutic targets for this disorder.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Post-translational modifications of mutant huntingtin target it for degradation.

Katie Vicari

References

  1. Bates, G. et al. Huntington's Disease. (Oxford University Press, New York, 2002).

    Google Scholar 

  2. Yamamoto, A. et al. Cell 101, 57–66 (2000).

    Article  CAS  Google Scholar 

  3. Arrasate, M. et al. Nature 431, 805–810 (2004).

    Article  CAS  Google Scholar 

  4. Roze, E. et al. Curr. Opin. Neurol. 21, 497–503 (2008).

    Article  CAS  Google Scholar 

  5. Gu, X. et al. Neuron 6, 828–840 (2009).

    Article  Google Scholar 

  6. Thompson, L.M. et al. J. Cell Biol. 187, 1083–1099 (2009).

    Article  CAS  Google Scholar 

  7. Jeong, H. et al. Cell 137, 60–72 (2009).

    Article  CAS  Google Scholar 

  8. Ravikumar, B. et al. Nat. Genet. 36, 585–595 (2004).

    Article  CAS  Google Scholar 

  9. Kazantsev, A.G. & Thompson, L.M. Nat. Rev. Drug Discov. 7, 854–868 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dimitri Krainc.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krainc, D. Huntington's disease: tagged for clearance. Nat Med 16, 32–33 (2010). https://doi.org/10.1038/nm0110-32

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0110-32

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing