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Integrin indecision

Nature Medicine volume 8, pages 14–16 (2002)Cite this article

Antagonists of the αvβ3 and αvβ5 integrins inhibit angiogenesis in cancer, arthritis and ischemic retinopathy. However, a surprising new report suggests that knockout mice lacking β3 and/or β5 integrins show enhanced, rather than reduced angiogenesis. (pages 27–34)

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Figure 1: Possible roles of αvβ3 integrin in angiogenesis.

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  1. Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium

    Peter Carmeliet

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  1. Peter Carmeliet
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Carmeliet, P. Integrin indecision. Nat Med 8, 14–16 (2002). https://doi.org/10.1038/nm0102-14

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