Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Macrophages dispose of catecholamines in adipose tissue

Recent research has identified sympathetic neuron–associated macrophages in adipose tissue that take up and degrade catecholamines released from neurons. Obesity and aging enhance this system, decreasing responses to cold stress and starvation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The role of NE-degrading macrophages in obesity and aging.

Katie Vicari/Springer Nature

References

  1. Czech, M.P. Nat. Med. 23, 804–814 (2017).

    Article  CAS  Google Scholar 

  2. Bartness, T.J., Vaughan, C.H. & Song, C.K. Int. J. Obes. 34 (Suppl. 1), S36–S42 (2010).

    Article  Google Scholar 

  3. Guilherme, A. et al. Mol. Metab. 6, 781–796 (2017).

    Article  CAS  Google Scholar 

  4. Pirzgalska, R.M. et al. Nat. Med. 23, 1309–1318 (2017).

    Article  CAS  Google Scholar 

  5. Camell, C.D. et al. Nature 550, 119–123 (2017).

    Article  CAS  Google Scholar 

  6. Guo, T. et al. eLife 3, e03245 (2014).

    Article  Google Scholar 

  7. Amano, S.U. et al. Cell Metab. 19, 162–171 (2014).

    Article  CAS  Google Scholar 

  8. Salter, M.W. & Stevens, B. Nat. Med. 23, 1018–1027 (2017).

    Article  CAS  Google Scholar 

  9. Nguyen, K.D. et al. Nature 480, 104–108 (2011).

    Article  CAS  Google Scholar 

  10. Fischer, K. et al. Nat. Med. 23, 623–630 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael P Czech.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Czech, M. Macrophages dispose of catecholamines in adipose tissue. Nat Med 23, 1255–1257 (2017). https://doi.org/10.1038/nm.4440

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4440

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing