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Improving treatment of liver metastases by targeting nonangiogenic mechanisms

Nature Medicine volume 22, pages 1209–1210 (2016)Cite this article

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A recent study confirms an association between vessel co-option and resistance to bevacizumab, an anti-vascular endothelial growth factor-A (VEGFA) antibody, in patients with liver metastases. The authors suggest a combined therapeutic strategy that reduces co-option in mice.

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Figure 1: Potential strategies for overcoming resistance to anti-VEGFA therapy.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Kyrre E. Emblem is in the Department of Diagnostic Physics, The Intervention Centre, Oslo University Hospital, Oslo, Norway.,

    Kyrre E Emblem

  2. Department of Radiation Oncology, Rakesh K. Jain is at the Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.,

    Rakesh K Jain

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  1. Kyrre E Emblem
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  2. Rakesh K Jain
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Correspondence to Kyrre E Emblem.

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Competing interests

K.E.E. has no conflicts of interest. E.K.J. has received consultant fees from Enlight, Ophthotech, SPARC and SynDevRx, owns equity in Enlight, Ophthotech, SynDevRx and XTuit, and serves on the Board of Directors of XTuit and the Boards of Trustees of Tekla Healthcare Investors, Tekla Life Sciences Investors, Tekla Healthcare Opportunities Fund and Tekla World Healthcare Fund. No funding or reagents from these companies were used in this study.

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Emblem, K., Jain, R. Improving treatment of liver metastases by targeting nonangiogenic mechanisms. Nat Med 22, 1209–1210 (2016). https://doi.org/10.1038/nm.4228

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