Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.
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Acknowledgements
M.P. is supported by NIH grants AI110334 and AI104278. M.L. is supported by NIH grants AI106468, AI114235, AI117841, AI120008 and AI098487.
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Paiardini, M., Lichterfeld, M. Follicular T helper cells: hotspots for HIV-1 persistence. Nat Med 22, 711–712 (2016). https://doi.org/10.1038/nm.4138
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DOI: https://doi.org/10.1038/nm.4138
