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Shifts in macrophage cytokine production drive muscle fibrosis

Nature Medicine volume 21, pages 665–666 (2015)Cite this article

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Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

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Figure 1: Acute muscle injury leads to FAP proliferation and muscle invasion by myeloid cells.

Marina Corral Spence/Nature Publishing Group

References

  1. Joe, A.W. et al. Nat. Cell Biol. 12, 153–163 (2010).

    Article  CAS  Google Scholar 

  2. Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Nat. Cell Biol. 12, 143–152 (2010).

    Article  CAS  Google Scholar 

  3. Tidball, J.G., Dorshkind, K. & Wehling-Henricks, M. Development 141, 1184–1196 (2014).

    Article  CAS  Google Scholar 

  4. Finsterer, J. & Stollberger, C. Cardiology 99, 1–19 (2003).

    Article  Google Scholar 

  5. Forst, J. & Forst, R. Neuromuscul. Disord. 9, 176–181 (1999).

    Article  CAS  Google Scholar 

  6. Vidal, B. et al. Genes Dev. 22, 1747–1752 (2008).

    Article  CAS  Google Scholar 

  7. Wehling-Henricks, M. et al. PLoS ONE 5, e10763 (2010).

    Article  Google Scholar 

  8. Lemos, D.R. et al. Nat. Med. 21, 786–794 (2015).

    Article  CAS  Google Scholar 

  9. Akhmetshina, A. et al. FASEB J. 22, 2214–2222 (2008).

    Article  CAS  Google Scholar 

  10. Campbell, J. et al. J. Immunol. 173, 6928–6937 (2004).

    Article  CAS  Google Scholar 

  11. Manley, P.W. et al. Biochim. Biophys. Acta 1804, 445–453 (2010).

    Article  CAS  Google Scholar 

  12. Deng, B., Wehling-Henricks, M., Villalta, S.A., Wang, Y. & Tidball, J.G. J. Immunol. 189, 3669–3680 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. and in the Department of Pathology and Laboratory Medicine, James G. Tidball is in the Molecular, Cellular and Integrative Physiology Program, University of California Los Angeles, Los Angeles, California, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California.,

    James G Tidball

  2. Both James G. Tidball and Michelle Wehling-Henricks are in the Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California.,

    James G Tidball & Michelle Wehling-Henricks

Authors
  1. James G Tidball
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  2. Michelle Wehling-Henricks
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Correspondence to James G Tidball.

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Tidball, J., Wehling-Henricks, M. Shifts in macrophage cytokine production drive muscle fibrosis. Nat Med 21, 665–666 (2015). https://doi.org/10.1038/nm.3896

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