Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.
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References
Rascovsky, K. et al. Brain 134, 2456–2477 (2011).
Roberson, E.D. Neurology 65, 719–725 (2005).
Seelaar, H. et al. Neurology 71, 1220–1226 (2008).
Skibinski, G. et al. Nat. Genet. 37, 806–808 (2005).
Ghazi-Noori, S. et al. Brain 135, 819–832 (2012).
Gascon, E. et al. Nat. Med. 20, 1444–1451 (2014).
Dutta, R. et al. Ann. Neurol. 73, 637–645 (2013).
Gascon, E. & Gao, F.B. J. Neurogenet. 28, 30–40 (2014).
Siomi, H. & Siomi, M.C. Nat. Cell Biol. 11, 1049–1051 (2009).
Goodall, E.F., Heath, P.R., Bandmann, O., Kirby, J. & Shaw, P.J. Front. Cell. Neurosci. 7, 178 (2013).
Wang, F. et al. Science 334, 693–697 (2011).
O'Connor, E.C., Bariselli, S. & Bellone, C. Eur. J. Neurosci. 39, 1114–1129 (2014).
Kawahara, Y. et al. Nature 427, 801 (2004).
Roberson, E.D. Ann. Neurol. 72, 837–849 (2012).
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Arrant, A., Roberson, E. MicroRNA-124 modulates social behavior in frontotemporal dementia. Nat Med 20, 1381–1383 (2014). https://doi.org/10.1038/nm.3768
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DOI: https://doi.org/10.1038/nm.3768
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