Altered stem cell homeostasis underlies functional tissue decline during muscle aging and disease progression. Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration
Cell Research Open Access 24 August 2020
-
Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Cell Death & Differentiation Open Access 22 July 2019
-
Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
Journal of Translational Medicine Open Access 20 February 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Vicari/Nature Publishing Group
References
Piccirillo, R., Demontis, F., Perrimon, N. & Goldberg, A.L. Dev. Dyn. 243, 201–215 (2014).
Price, F.D. et al. Nat. Med. 20, 1174–1181 (2014).
Tierney, M.T. et al. Nat. Med. 20, 1182–1186 (2014).
Kuang, S., Kuroda, K., Le Grand, F. & Rudnicki, M.A. Cell 129, 999–1010 (2007).
Troy, A. et al. Cell Stem Cell 11, 541–553 (2012).
Murphy, M.M., Lawson, J.A., Mathew, S.J., Hutcheson, D.A. & Kardon, G. Development 138, 3625–3637 (2011).
Sambasivan, R. et al. Development 138, 3647–3656 (2011).
Bernet, J.D. et al. Nat. Med. 20, 265–271 (2014).
Chakkalakal, J.V., Jones, K.M., Basson, M.A. & Brack, A.S. Nature 490, 355–360 (2012).
Conboy, I.M. et al. Nature 433, 760–764 (2005).
Sousa-Victor, P. et al. Nature 506, 316–321 (2014).
Rawlings, J.S., Rosler, K.M. & Harrison, D.A. J. Cell Sci. 117, 1281–1283 (2004).
Doles, J., Storer, M., Cozzuto, L., Roma, G. & Keyes, W.M. Genes Dev. 26, 2144–2153 (2012).
Cosgrove, B.D. et al. Nat. Med. 20, 255–264 (2014).
Freund, A., Orjalo, A.V., Desprez, P.Y. & Campisi, J. Trends Mol. Med. 16, 238–246 (2010).
Pardanani, A. et al. Leukemia 25, 218–225 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Doles, J., Olwin, B. The impact of JAK-STAT signaling on muscle regeneration. Nat Med 20, 1094–1095 (2014). https://doi.org/10.1038/nm.3720
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3720
This article is cited by
-
Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis
Nature Reviews Rheumatology (2023)
-
Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Cell Death & Differentiation (2020)
-
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration
Cell Research (2020)
-
Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
Journal of Translational Medicine (2018)
