Pharmacologic modulation of iron metabolism may be a potential strategy to control infection caused by the intracellular bacteria Salmonella enterica var. Typhimurium (S. typhimurium) (pages 419–424). The molecular mechanism involves the estrogen-related receptor γ (ERRγ) in the liver, which can be targeted with an inverse agonist to improve survival of infected animals.
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Lokken, K., Tsolis, R. & Bäumler, A. Hypoferremia of infection: a double-edged sword?. Nat Med 20, 335–337 (2014). https://doi.org/10.1038/nm.3526
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DOI: https://doi.org/10.1038/nm.3526
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