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Sirt1–Claudin-1 crosstalk regulates renal function

Nature Medicine volume 19, pages 1371–1372 (2013)Cite this article

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Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (pages 1496–1504).

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Figure 1: Regulation of podocyte function by proximal tubule Sirt1 in healthy and diabetic kidneys.

Katie Vicari

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Authors and Affiliations

  1. Deepak Nihalani and Katalin Susztak are in the Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Deepak Nihalani & Katalin Susztak

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  1. Deepak Nihalani
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  2. Katalin Susztak
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Correspondence to Katalin Susztak.

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Nihalani, D., Susztak, K. Sirt1–Claudin-1 crosstalk regulates renal function. Nat Med 19, 1371–1372 (2013). https://doi.org/10.1038/nm.3386

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