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Therapeutically reeducating macrophages to treat GBM

Glioblastoma multiforme (GBM) is the most common type of aggressive malignant brain cancer. The current lack of successful therapeutics means that this disease has a dismal prognosis. However, a new study in mice offers hope for patients with GBM by demonstrating the efficacy of a novel drug that targets GBM-associated macrophages (pages 1264–1272).

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Figure 1: Tumor-macrophage interactions in glioma.

Katie Vicari

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Correspondence to Mikael J Pittet.

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Garris, C., Pittet, M. Therapeutically reeducating macrophages to treat GBM. Nat Med 19, 1207–1208 (2013). https://doi.org/10.1038/nm.3355

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