Metabolic alterations, such as those caused by mutations in the enzyme isocitrate dehydrogenase (IDH), define a clinically distinct subset of primary brain cancers. Expression of BCAT1 is now reported as a new metabolic change defining brain cancers without IDH mutations (pages 901–908).
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Mayers, J., Vander Heiden, M. BCAT1 defines gliomas by IDH status. Nat Med 19, 816–817 (2013). https://doi.org/10.1038/nm.3263
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DOI: https://doi.org/10.1038/nm.3263
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