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Waking up HSCs: a new role for E-selectin

Nature Medicine volume 18, pages 1613–1614 (2012)Cite this article

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Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained unclear. A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651–1657).

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Figure 1: HSCs in the bone marrow vascular niche.

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  1. Malcolm A.S. Moore is in the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,

    Malcolm A S Moore

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  1. Malcolm A S Moore
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Correspondence to Malcolm A S Moore.

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Declaration: M.A.S.M. holds patents on granulocyte colony–stimulating factor [AU: with which patent office?] and receives royalties from Amgen.

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Moore, M. Waking up HSCs: a new role for E-selectin. Nat Med 18, 1613–1614 (2012). https://doi.org/10.1038/nm.2992

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