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Not just a rush of blood to the head

Angiogenesis is a key feature of central nervous system injury. A neovessel-derived signal mediated by prostacyclin triggers axonal sprouting and functional recovery in a mouse model of inflammatory spinal cord injury (pages 1658–1664). Are such angiocrine signals relevant to neurovascular remodeling and recovery in other neurological contexts?

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Figure 1: The regenerative neurovascular niche.

References

  1. Quaegebeur, A., Lange, C. & Carmeliet, P. Neuron 71, 406–424 (2011).

    Article  CAS  Google Scholar 

  2. Ergul, A., Alhusban, A. & Fagan, S.C. Stroke 43, 2270–2274 (2012).

    Article  Google Scholar 

  3. Oudega, M. Cell Tissue Res. 349, 269–288 (2012).

    Article  CAS  Google Scholar 

  4. Loy, D.N. et al. J. Comp. Neurol. 445, 308–324 (2002).

    Article  Google Scholar 

  5. Muramatsu, R. et al. Nat. Med. 18, 1658–1664 (2012).

    Article  CAS  Google Scholar 

  6. Kerschensteiner, M. et al. J. Exp. Med. 200, 1027–1038 (2004).

    Article  CAS  Google Scholar 

  7. Bareyre, F.M. et al. Nat. Neurosci. 7, 269–277 (2004).

    Article  CAS  Google Scholar 

  8. Brown, C.E., Li, P., Boyd, J.D., Delaney, K.R. & Murphy, T.H. J. Neurosci. 27, 4101–4109 (2007).

    Article  CAS  Google Scholar 

  9. Dray, C., Rougon, G. & Debarbieux, F. Proc. Natl. Acad. Sci. USA 106, 9459–9464 (2009).

    Article  CAS  Google Scholar 

  10. Chen, J. et al. Ann. Neurol. 53, 743–751 (2003).

    Article  CAS  Google Scholar 

  11. Thiyagarajan, M., Fernández, J.A., Lane, S.M., Griffin, J.H. & Zlokovic, B.V. J. Neurosci. 28, 12788–12797 (2008).

    Article  CAS  Google Scholar 

  12. Zheng, J.Q. & Poo, M.M. Annu. Rev. Cell Dev. Biol. 23, 375–404 (2007).

    Article  CAS  Google Scholar 

  13. Ohab, J.J., Fleming, S., Blesch, A. & Carmichael, S.T. J. Neurosci. 26, 13007–13016 (2006).

    Article  CAS  Google Scholar 

  14. Overman, J.J. et al. Proc. Natl. Acad. Sci. USA 109, E2230–E2239 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to S Thomas Carmichael.

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Brumm, A., Carmichael, S. Not just a rush of blood to the head. Nat Med 18, 1609–1610 (2012). https://doi.org/10.1038/nm.2990

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