The enthesis is the region at the junction between tendon and bone and has been suggested to be a key target in spondyloarthritic diseases. This zone is now shown to contain a unique population of resident T cells, which, when activated by the cytokine interleukin-23 (IL-23), can promote pathogenesis that is characteristic of spondyloarthritis (pages 1069–1076).
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I.B.M. received honoraria from Janssen and Novartis.
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Lories, R., McInnes, I. Primed for inflammation: enthesis-resident T cells. Nat Med 18, 1018–1019 (2012). https://doi.org/10.1038/nm.2854
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DOI: https://doi.org/10.1038/nm.2854
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