Clinicians note that bariatric operations can dramatically resolve type 2 diabetes, often before and out of proportion to postoperative weight loss. Now two randomized controlled trials formally show superior results from surgical compared with medical diabetes care, including among only mildly obese patients. The concept of 'metabolic surgery' to treat diabetes has taken a big step forward.
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References
Thaler, J.P. & Cummings, D.E. Endocrinology 150, 2518–2525 2009).
Rubino, F., Schauer, P.R., Kaplan, L.M. & Cummings, D.E. Annu. Rev. Med. 61, 393–411 2010).
Rubino, F., Kaplan, L.M., Schauer, P.R. & Cummings, D.E. Ann. Surg. 251, 399–405 2010).
Zimmet, P., Alberti, K.G., Rubino, F. & Dixon, J.B. Lancet 378, 108–110 2011).
NIH. Ann. Intern. Med. 115, 956–961 1991).
Mingrone, G. et al. N. Engl. J. Med. doi:10.1056/NEJMoa1200111 (26 March 2012).
Schauer, P.R. et al. N. Engl. J. Med. doi: 10.1056/NEJMoa1200225 (26 March 2012).
Sjöström, L. et al. N. Engl. J. Med. 351, 2683–2693 2004).
Sjöström, L. et al. J. Am. Med. Assoc. 307, 56–65 2012).
Sjöström, L. et al. N. Engl. J. Med. 357, 741–752 2007).
Adams, T.D. et al. N. Engl. J. Med. 357, 753–761 2007).
Manson, J.E. et al. N. Engl. J. Med. 349, 523–534 2003).
Gerstein, H.C. et al. N. Engl. J. Med. 358, 2545–2559 2008).
Buchwald, H. et al. J. Am. Med. Assoc. 292, 1724–1737 2004).
Rejeski, W.J. et al. N. Engl. J. Med. 366, 1209–1217 2012).
Dixon, J.B. et al. J. Am. Med. Assoc. 299, 316–323 2008).
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Dr. Cummings is a Principal Investigator on the COSMID trial, which is funded by Johnson & Johnson.
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Cummings, D. Metabolic surgery for type 2 diabetes. Nat Med 18, 656–658 (2012). https://doi.org/10.1038/nm.2773
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DOI: https://doi.org/10.1038/nm.2773
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