Epilepsy complicates the clinical course of many patients with brain tumors, particularly gliomas. A mouse model of glioma now indicates that glioma cells release glutamate, causing tumor-related seizures (pages 1269–1274). Sulfasalazine, an approved therapeutic for Crohn's disease, can block glutamate release and improve seizures in these mice; therefore, this drug may also have potential antiepileptic effects in humans.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Chang, E.F. et al. J. Neurosurg. 108, 227–235 (2008).
Kurzwelly, D., Herrlinger, U. & Simon, M. Adv. Tech. Stand. Neurosurg. 35, 81–111 (2010).
Simon, M., Neuloh, G., von Lehe, M., Meyer, B. & Schramm, J. J. Neurosurg. 110, 685–695 (2009).
Klein, M. et al. Ann. Neurol. 54, 514–520 (2003).
Luyken, C. et al. Epilepsia 44, 822–830 (2003).
Buckingham, S.C. et al. Nat. Med. 17, 1269–1274 (2011)
Shamji, M.F., Fric-Shamji, E.C. & Benoit, B.G. Neurosurg. Rev. 32, 275–284 (2009).
Löscher, W. Seizure 20, 359–368 (2011).
Chung, W.J. et al. J. Neurosci. 25, 7101–7110 (2005).
Lo, M., Wang, Y.Z. & Gout, P.W. J. Cell. Physiol. 215, 593–602 (2008).
Bridges, R.J. Br. J. Pharmacol. 2011 May 13 [Epub ahead of print].
Robe, P.A. et al. BMC Cancer 9, 372 (2009).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Simon, M., von Lehe, M. Glioma-related seizures: glutamate is the key. Nat Med 17, 1190–1191 (2011). https://doi.org/10.1038/nm.2510
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2510
This article is cited by
-
A pathway map of glutamate metabolism
Journal of Cell Communication and Signaling (2016)
-
Decreased inhibitory neuronal activity in patients with frontal lobe brain tumors with seizure presentation: Preliminary study using magnetoencephalography
Acta Neurochirurgica (2013)