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Treg cells: patrolling a dangerous neighborhood

Nature Medicine volume 17, pages 929–930 (2011)Cite this article

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How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo functional specialization to limit the magnitude of the germinal center response, and they may contribute to our understanding of how germinal center–mediated autoimmunity is prevented (pages 975–982 and 983–988).

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Figure 1: TFR cell–mediated regulation of the germinal center reaction.

References

  1. Guo, W. et al. J. Exp. Med. 207, 2225–2237 (2010).

    Article  CAS  Google Scholar 

  2. Ray, S.K., Putterman, C. & Diamond, B. Proc. Natl. Acad. Sci. USA 93, 2019–2024 (1996).

    Article  CAS  Google Scholar 

  3. Vinuesa, C.G., Sanz, I. & Cook, M.C. Nat. Rev. Immunol. 9, 845–857 (2009).

    Article  CAS  Google Scholar 

  4. Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    Article  CAS  Google Scholar 

  5. Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Cell 133, 775–787 (2008).

    Article  CAS  Google Scholar 

  6. Godfrey, V.L., Wilkinson, J.E. & Russell, L.B. Am. J. Pathol. 138, 1379–1387 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Huter, E.N., Natarajan, K., Torgerson, T.R., Glass, D.D. & Shevach, E.M. J. Invest. Dermatol. 130, 1391–1399 (2010).

    Article  CAS  Google Scholar 

  8. Seo, S.J. et al. Immunity 16, 535–546 (2002).

    Article  CAS  Google Scholar 

  9. Lim, H.W., Hillsamer, P., Banham, A.H. & Kim, C.H. J. Immunol. 175, 4180–4183 (2005).

    Article  CAS  Google Scholar 

  10. Linterman, M.A. et al. Nat. Med. 17, 975–982 (2011).

    Article  CAS  Google Scholar 

  11. Chung, Y. et al. Nat. Med. 17, 983–988 (2011).

    Article  CAS  Google Scholar 

  12. Campbell, D.J. & Koch, M.A. Nat. Rev. Immunol. 11, 119–130 (2011).

    Article  CAS  Google Scholar 

  13. Schwartzberg, P.L., Mueller, K.L., Qi, H. & Cannons, J.L. Nat. Rev. Immunol. 9, 39–46 (2009).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Daniel J. Campbell and Meghan A. Koch are at the Benaroya Research Institute, Seattle, Washington, USA.,

    Daniel J Campbell & Meghan A Koch

  2. Daniel J. Campbell is also in the Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA.,

    Daniel J Campbell

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  1. Daniel J Campbell
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  2. Meghan A Koch
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Correspondence to Daniel J Campbell.

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Campbell, D., Koch, M. Treg cells: patrolling a dangerous neighborhood. Nat Med 17, 929–930 (2011). https://doi.org/10.1038/nm.2433

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