Abstract
We studied here the long-term maintenance of distinct populations of T helper type 1 (TH1)-lineage cells in vivo and found that effector TH1 cells, defined by their secretion of interferon-γ (IFN-γ), are short-lived and do not efficiently develop into long-term memory TH1 cells. In contrast, a population of activated TH1-lineage cells that did not secrete IFN-γ after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-γ upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-γ–producing to resting memory cells, is relatively limited in vivo and support a revised model for TH1 memory differentiation.
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Acknowledgements
We thank B. Marshal for editorial assistance and X. Tai for technical help with cell preparation.
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Wu, Cy., Kirman, J., Rotte, M. et al. Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo. Nat Immunol 3, 852–858 (2002). https://doi.org/10.1038/ni832
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DOI: https://doi.org/10.1038/ni832
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