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Maintenance and modulation of T cell polarity

Nature Immunology volume 7, pages 1143–1149 (2006)Cite this article

Abstract

As T cells move through the lymphatics and tissues, chemokine receptors, adhesion molecules, costimulatory molecules and antigen receptors engage their ligands in the microenvironment and contribute to establishing and maintaining cell polarity. Cytoskeletal assemblies, surface proteins and vesicle traffic are essential components of polarity and probably stabilize the activity of lymphocytes that must negotiate their 'noisy' environment. An additional component of polarity is a family of polarity proteins in T cells that includes Dlg, Scrib and Lgl, as well as a complex of partitioning-defective proteins. Ultimately, the strength of a T cell response may rely on correct T cell polarization. Therefore, loss of polarity regulators or guidance cues may interfere with T cell activation.

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Figure 1: Five polarity systems in motile T lymphocytes.
Figure 2: Distinct zones in motile lymphocytes.
Figure 3: Early events in polarity modulation.
Figure 4: Five polarity systems in established T cell couples.

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Acknowledgements

We thank J. Gilden for critical reading of the manuscript, and C. Lin for assistance with graphics.

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  1. Department of Pathology, University of California at San Francisco, San Francisco, 94143-0511, California, USA

    Matthew F Krummel

  2. Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, 22908-0577, Virginia, USA

    Ian Macara

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Krummel, M., Macara, I. Maintenance and modulation of T cell polarity. Nat Immunol 7, 1143–1149 (2006). https://doi.org/10.1038/ni1404

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