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Bacterial cell walls, innate immunity and immunoadjuvants

Jack Strominger recounts his seminal work and contributions to understanding bacterial cell wall components, and thus how penicillin functions, and the implications of these discoveries for immunology.

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Figure 1: Structure of the peptidoglycans of S. aureus and Escherichia coli showing their cleavage by various bacteriolytic enzymes and the location of Nod 1 and Nod 2 ligands that have been identified.

References

  1. Strominger, J.L. (2006). The tortuous journey of a biochemist to Immunoland and what he found there (prefatory chapter). Annu. Rev. Immunol. 24, 1–31 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Park, J.T. Uridine-5′-pyrophosphate derivatives. III. Amino acid-containing derivatives. J. Biol. Chem. 194, 897–904 (1952).

    CAS  PubMed  Google Scholar 

  3. Strominger, J.L. The amino acid sequence in the uridine nucleotide-peptide from Staphylococcus aureus. C. R. Trav. Lab. Carlsberg 31, 181–192 (1959).

    CAS  Google Scholar 

  4. Park, J.T. & Strominger, J.L. Mode of action of penicillin. Biochemical basis for the mechanism of action of penicillin and for its selective toxicity. Science 125, 99–101 (1957).

    Article  CAS  PubMed  Google Scholar 

  5. Nathenson, S. & Strominger, J.L. Effects of penicillin on the biosynthesis of the cell walls of Escherichia coli and Staphylococcus aureus. J. Pharmacol. Exp. Therap. 131, 1–6 (1961).

    CAS  Google Scholar 

  6. Strominger, J.L. Penicillin-sensitive enzymatic reactions in bacterial cell wall synthesis. in Harvey Lectures, Series 64 179–213 (Academic Press, New York, 1970).

    Google Scholar 

  7. Tipper, D.J. & Strominger, J.L. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc. Natl. Acad. Sci. USA 54, 1133–1141 (1965).

    Article  CAS  PubMed  Google Scholar 

  8. Izaki, K., Matsuhashi, M. & Strominger, J.L. Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions. Proc. Natl. Acad. Sci. USA 55, 656–663 (1966).

    Article  CAS  PubMed  Google Scholar 

  9. Mandelstam, M.H. & Strominger, J.L. On the structure of the cell wall of Staphylococcus aureus (Copenhagen). Biochem. Res. Commun. 5, 466–476 (1961).

    Article  CAS  Google Scholar 

  10. Strominger, J.L. & Ghuysen, J,-M. Mechanisms of enzymatic bacteriolysis. Science 156, 213–221 (1967).

    Article  CAS  PubMed  Google Scholar 

  11. Juergens, W.G., Sanderson, A.R. & Strominger, J.L. Chemical basis for an immunological specificity of a strain of Staphylococcus aureus. J. Exp. Med. 117, 925–935 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Adam, A., Petit, J.F., Lefrancier, P. & Lederer, E. Muramyl peptides. Chemical structure, biological activity and mechanism of action. Mol. Cell. Biochem. 41, 27–47 (1981).

    Article  CAS  PubMed  Google Scholar 

  13. Strominger, J.L. & Threnn, R.H. Accumulation of a uridine nucleotide in Staphylococcus aureus as the consequence of lysine deprivation. Biochim. Biophys. Acta 36, 83–92 (1959).

    Article  CAS  PubMed  Google Scholar 

  14. Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783–801 (2006).

    Article  CAS  Google Scholar 

  15. Wilmanski, J.M., Petnicki-Ocwieja, T. & Kobayashi, K. NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J. Leukoc. Biol. published online 17 September (2007).

  16. Girardin, S.E. & Philpott, D.J. Mini-review: the role of peptidoglycan recognition in innate immunity. Eur. J. Immunol. 34, 1777–1782 (2004).

    Article  CAS  PubMed  Google Scholar 

  17. Matsuhashi, M. & Strominger, J.L. Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. I. Enzymatic synthesis by strains of Escherichia coli. J. Biol. Chem. 239, 2454–2463 (1964).

    CAS  PubMed  Google Scholar 

  18. Fitzgerald, K.A. & Golenbock, D.T. Immunology. The shape of things to come. Science 316, 1574–1576 (2007).

    Article  CAS  PubMed  Google Scholar 

  19. Mata-Haro, V. et al. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 316, 1628–1632 (2007).

    Article  CAS  Google Scholar 

  20. Ohto, U., Fukase, K., Miyake, K. & Satow, Y. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316, 1632–1634 (2007).

    Article  CAS  PubMed  Google Scholar 

  21. Brigl, M. & Brenner, M.B. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22, 817–890 (2004)

    Article  CAS  Google Scholar 

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Strominger, J. Bacterial cell walls, innate immunity and immunoadjuvants. Nat Immunol 8, 1269–1271 (2007). https://doi.org/10.1038/ni1207-1269

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