New evidence suggests that mediators of T cell quiescence and immune suppression converge on a common transcriptional program. Tob, a member of a family of anti-proliferation regulators, actively maintains T cell quiescence by interacting with components of the TGF-β signal transduction pathway.
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Hua, X., Thompson, C. Quiescent T cells: actively maintaining inactivity. Nat Immunol 2, 1097–1098 (2001). https://doi.org/10.1038/ni1201-1097
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DOI: https://doi.org/10.1038/ni1201-1097
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