Abstract
How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of β-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.
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Acknowledgements
The authors thank F.Y. Liew, P. Garside, A. Mowat and I. McInnes for discussions and for comments on the manuscript. Supported by Cancer Research UK.
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Jamieson, T., Cook, D., Nibbs, R. et al. The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol 6, 403–411 (2005). https://doi.org/10.1038/ni1182
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DOI: https://doi.org/10.1038/ni1182
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