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Mechanisms of suppression by suppressor T cells

Nature Immunology volume 6, pages 338–344 (2005)Cite this article

Abstract

Mechanisms of immunosuppression by CD4+CD25+ suppressor T cells have been addressed using many in vitro and in vivo conditions. However, those studies have not yielded a single mode of action. This review will discuss the mechanisms of suppression, which include the local secretion of cytokines such as TGF-β and direct cell contact through binding of cell surface molecules such as CTLA-4 on suppressor T cells to CD80 and CD86 molecules on effector T cells. Suppression requires the appropriate colocalization of suppressor and effector T cells in different tissue and may involve the interference with T cell receptor signaling that triggers transcription factors important in regulating effector cell function.

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Figure 1: CTLA-4 and CD80 and/or CD86 in suppression.
Figure 2: Making effector T cells insensitive to suppression.
Figure 3: TGF-β in the suppression of CD8 T cells.

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Acknowledgements

The help of L. Benson and L. von Boehmer in preparing this manuscript is acknowledged. Supported by the National Institutes of Health (R37AI51378).

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    Harald von Boehmer

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von Boehmer, H. Mechanisms of suppression by suppressor T cells. Nat Immunol 6, 338–344 (2005). https://doi.org/10.1038/ni1180

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