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NDP52: the missing link between ubiquitinated bacteria and autophagy

Mammalian cells ubiquitinate bacteria that erroneously enter the cytosol and target these intruding microbes for destruction by autophagy. New work shows that the protein NDP52 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds these invaders.

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Figure 1: Host response to cytosolic bacteria.

Kim Caesar

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Correspondence to Craig R Roy.

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Ivanov, S., Roy, C. NDP52: the missing link between ubiquitinated bacteria and autophagy. Nat Immunol 10, 1137–1139 (2009). https://doi.org/10.1038/ni1109-1137

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