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Fueling regulation: IL-2 keeps CD4+ Treg cells fit

Nature Immunology volume 6, pages 1071–1072 (2005)Cite this article

Naturally occurring regulatory T cells are key in controlling autoimmune and inflammatory responses. New data indicate that although interleukin 2 signals are not essential for regulatory T cell development in the thymus, they are critical for maintenance of these cells in the periphery.

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Figure 1: IL-2 is dispensable for the development of Treg cells in the thymus but is essential for their peripheral maintenance.

Katie Ris

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  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK

    Kevin J Maloy & Fiona Powrie

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  1. Kevin J Maloy
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  2. Fiona Powrie
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Maloy, K., Powrie, F. Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat Immunol 6, 1071–1072 (2005). https://doi.org/10.1038/ni1105-1071

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