The physical location of key proteins may turn out to significantly influence the differentiation tack that a cell takes. If clusters of antigen receptors include interferon-γ receptors in their midst, the fate of that T cell may be tipped.
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Sims, T., Dustin, M. A polarizing situation. Nat Immunol 5, 1012–1013 (2004). https://doi.org/10.1038/ni1004-1012
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DOI: https://doi.org/10.1038/ni1004-1012