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Cytoplasmic double-stranded DNA sensor

Nature Immunology volume 8, pages 907–908 (2007)Cite this article

A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA.

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Figure 1: In the innate immune system, cytoplasmic sensor molecules detect invasion of viruses or bacteria, then activate expression of cytokines, including type I interferon, and inhibit their multiplication.

Katie Ris-Vicari

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Authors and Affiliations

  1. Mitsutoshi Yoneyama and Takashi Fujita are in the Laboratory of Molecular Genetics, Institute for Virus Research, and Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8507, Japan. tfujita@virus.kyoto-u.ac.jp,

    Mitsutoshi Yoneyama & Takashi Fujita

Authors
  1. Mitsutoshi Yoneyama
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  2. Takashi Fujita
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Yoneyama, M., Fujita, T. Cytoplasmic double-stranded DNA sensor. Nat Immunol 8, 907–908 (2007). https://doi.org/10.1038/ni0907-907

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