Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Calcium-independent calcineurin regulation

Nature Immunology volume 4, pages 821–823 (2003)Cite this article

Calcineurin is negatively regulated by calcipressin 1. Analysis of calcipressin-deficient mice shows that survival of T helper type 1 cells is dependent on calcipressin, demonstrating another function for the regulation of calcineurin activity in T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Multiple levels of regulation occur in the calcium-calcineurin-NFAT pathway.

References

  1. Guan, K.L. & Dixon, J.E. Science 249, 553–556 (1990).

    Article  CAS  Google Scholar 

  2. Clipstone, N.A. & Crabtree, G.R. Nature 357, 695–697 (1992).

    Article  CAS  Google Scholar 

  3. Ryeom, S., Greenwald, R.J., Sharpe, A.H. & McKeon, F. Nat. Immunol. 4, 874–881 (2003).

    Article  CAS  Google Scholar 

  4. Rothermel, B.A., Vega, R.B. & Williams, R.S. Trends Cardiovasc. Med. 13, 15–21 (2003).

    Article  CAS  Google Scholar 

  5. Ermak, G., Harris, C.D. & Davies, K.J. FASEB J. 16, 814–824 (2002).

    Article  CAS  Google Scholar 

  6. Zhang, X. et al. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185, 1837–1849 (1997).

    Article  CAS  Google Scholar 

  7. Yang, J. et al. Circ. Res. 87, E61–E68 (2000).

    Article  CAS  Google Scholar 

  8. Parry, R.V., Rumbley, C.A., Vandenberghe, L.H., June, C.H. & Riley, J.L. J. Immunol. 171, 166–174 (2003).

    Article  CAS  Google Scholar 

  9. Watanabe, N. et al. Nat. Immunol. 4, 670–679 (2003).

    Article  CAS  Google Scholar 

  10. Vega, R.B. et al. Proc. Natl. Acad. Sci. USA 100, 669–674 (2003).

    Article  CAS  Google Scholar 

  11. Lin, X., Sikkink, R.A., Rusnak, F. & Barber, D.L. J. Biol. Chem. 274, 36125–36131 (1999).

    Article  CAS  Google Scholar 

  12. Sun, L. et al. Immunity 8, 703–711 (1998).

    Article  CAS  Google Scholar 

  13. Miskin, J.E., Abrams, C.C., Goatley, L.C. & Dixon, L.K. Science 281, 562–565 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA

    Richard V Parry & Carl H June

Authors
  1. Richard V Parry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carl H June
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parry, R., June, C. Calcium-independent calcineurin regulation. Nat Immunol 4, 821–823 (2003). https://doi.org/10.1038/ni0903-821

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0903-821

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing