How do T cells that are specific for pancreatic islet cell antigens cause diabetes? A recent paper in Nature provides evidence from NOD mice that the killer T cells responsible increase their avidity as the disease progresses—removing the high avidity clones prevents disease.
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Nicholson, L., Kuchroo, V. Selecting killers: the line between life and death. Nat Immunol 1, 192–194 (2000). https://doi.org/10.1038/79726
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DOI: https://doi.org/10.1038/79726
