Host immunity requires cytotoxic lymphocytes that are able to move toward their targets but are also able to stop after identifying target cells and then establish stable cell-cell contact. A new study shows that separate phosphorylation sites in HS1, an actin cytoskeleton–remodeling factor, can regulate both processes.
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Beemiller, P., Krummel, M. Distinct functions for HS1 in chemosensory versus adhesive signaling. Nat Immunol 9, 833–834 (2008). https://doi.org/10.1038/ni0808-833
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DOI: https://doi.org/10.1038/ni0808-833
