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It takes nerve to dampen inflammation

Nature Immunology volume 6, pages 756–757 (2005)Cite this article

Stimulation of the vagus nerve via the α7 nicotinic acetylcholine receptor can dampen macrophage function. This anti-inflammatory pathway seems to signal through the Jak2-STAT3 pathway.

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Figure 1: Cholinergic stimulation ameliorates enteric inflammation during postoperative ileus via α7 nAChR–Jak2 interactions.

Katie Ris

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Authors and Affiliations

  1. The Herman and Susan Merinoff Center for Patient Oriented Research at The Institute for Medical Research at North Shore-LIJ, Manhasset, 11021, New York, USA

    Christine N Metz & Kevin J Tracey

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  1. Christine N Metz
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  2. Kevin J Tracey
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Metz, C., Tracey, K. It takes nerve to dampen inflammation. Nat Immunol 6, 756–757 (2005). https://doi.org/10.1038/ni0805-756

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