Mutations have been the driving force behind some of the most important discoveries in immunology, and the growing speed with which they can be found has impelled the use of random mutagenesis to create new immunological phenotypes in mice. Here we describe how phenotypes are created, detected and ascribed to genetic change.
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Supported by the National Institutes of Health (P01 AI070167).
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Beutler, B., Du, X. & Xia, Y. Precis on forward genetics in mice. Nat Immunol 8, 659–664 (2007). https://doi.org/10.1038/ni0707-659
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DOI: https://doi.org/10.1038/ni0707-659
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