Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Type I interferon and cancer immunoediting

Nature Immunology volume 6, pages 646–648 (2005)Cite this article

Tumors that develop in immunocompetent hosts show reduced immunogenicity because of selective pressure to escape destruction by immune cells. Type I interferons are involved in shaping this evasive response but, unexpectedly, tumor cells are not the main targets of these interferons.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Possible mechanisms for IFN-α/β in tumor suppression.

Katie Ris

References

  1. Smyth, M.J., Godfrey, D.I. & Trapani, J.A. Nat. Immunol. 2, 293–299 (2001).

    Article  CAS  Google Scholar 

  2. Dunn, G.P., Old, L.J. & Schreiber, R.D. Annu. Rev. Immunol. 22, 329–360 (2004).

    Article  CAS  Google Scholar 

  3. Dunn, G.P., Bruce, A.T., Ikeda, H., Old, L.J. & Schreiber, R.D. Nat. Immunol. 3, 991–998 (2002).

    Article  CAS  Google Scholar 

  4. Dunn, G.P., et al. Nat. Immunol. 6, 722–729 (2005).

    Article  CAS  Google Scholar 

  5. Dunn, G.P., Old, L.J. & Schreiber, R.D. Immunity 21, 137–148 (2004).

    Article  CAS  Google Scholar 

  6. Kaplan, D.H. et al. Proc. Natl. Acad. Sci. USA 95, 7556–7561 (1998).

    Article  CAS  Google Scholar 

  7. Smyth, M.J. et al. J. Exp. Med. 192, 755–760 (2000).

    Article  CAS  Google Scholar 

  8. Cretney, E. et al. J. Immunol. 168, 1356–1361 (2002).

    Article  CAS  Google Scholar 

  9. Gresser, I. & Belardelli, F. Cytokine Growth Factor Rev. 13, 111–118 (2002).

    Article  CAS  Google Scholar 

  10. Belardelli, F., Ferrantini, M., Proietti, E. & Kirkwood, J.M. Cytokine Growth Factor Rev. 13, 119–134 (2002).

    Article  CAS  Google Scholar 

  11. Takaoka, A. et al. Nature 424, 516–523 (2003).

    Article  CAS  Google Scholar 

  12. Casey, G. et al. Nat. Genet. 32, 581–583 (2002).

    Article  CAS  Google Scholar 

  13. Colonna, M., Krug, A. & Cella, M. Curr. Opin. Immunol. 14, 373–379 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author thanks J. Swann for discussions and the National Health and Medical Research Council of Australia for support.

Author information

Authors and Affiliations

  1. Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, 3002, Victoria, Australia

    Mark J Smyth

Authors
  1. Mark J Smyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smyth, M. Type I interferon and cancer immunoediting. Nat Immunol 6, 646–648 (2005). https://doi.org/10.1038/ni0705-646

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0705-646

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing