STATs are critical in immune responses to type 1 IFNs. The human and mouse pathways differ, partly due to differences in STAT2, but unpredicted responses after viral infections raise new questions.
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Acknowledgements
We thank J. Plotz, P. Plotz, D. O'Brien, W. Strober and R. Seder for their helpful comments.
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O'Shea, J., Visconti, R. Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat Immunol 1, 17–19 (2000). https://doi.org/10.1038/76872
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DOI: https://doi.org/10.1038/76872
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