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Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge

Nature Immunology volume 1, pages 17–19 (2000)Cite this article

STATs are critical in immune responses to type 1 IFNs. The human and mouse pathways differ, partly due to differences in STAT2, but unpredicted responses after viral infections raise new questions.

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Figure 1: Type 1 IFNs and the regulation of IFN-γ: mouse versus human.

Bob Crimi

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Acknowledgements

We thank J. Plotz, P. Plotz, D. O'Brien, W. Strober and R. Seder for their helpful comments.

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  1. Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N252, 10 Center Drive, Bethesda, MSC-1820, 20892-1820, MD, USA

    John J. O'Shea & Roberta Visconti

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  1. John J. O'Shea
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  2. Roberta Visconti
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O'Shea, J., Visconti, R. Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat Immunol 1, 17–19 (2000). https://doi.org/10.1038/76872

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