Without Brca1, T cells are lacking in numbers and maturity, but surprisingly not because of a lack of repair of rearranged TCR genes. The defects involve more than one p53-dependent mechanism.
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Bob Crimi
Bob Crimi
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Green, D., Schuler, M. T cell development: Some cells get all the breaks. Nat Immunol 1, 15–17 (2000). https://doi.org/10.1038/76868
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DOI: https://doi.org/10.1038/76868
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