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Immune control of HIV: the obstacles of HLA and viral diversity

Nature Immunology volume 2, pages 473–475 (2001)Cite this article

Abstract

The development of an effective vaccine for HIV requires a better understanding of immune responses. The challenge is to contain HIV in the context of individual host genetics and the ever increasing diversity of HIV.

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Figure 1: CTL epitope clustering in p17.
Figure 2: A comparison of the evolutionary distances of DNA encoding HIV-1 partial envelope gene sequences (C2-V5) through phylogenetic analysis.

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Acknowledgements

We thank B.Gaschen and R.Thakallapally for help with the illustrations.

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Authors and Affiliations

  1. Massachusetts General Hospital and Division of AIDS, Partners AIDS Research Center, Harvard Medical School, Boston, 02114, MA, USA

    Bruce D. Walker

  2. Los Alamos National Laboratory, Los Alamos, 87545, NM, USA

    Bette T. Korber

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  1. Bruce D. Walker
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Walker, B., Korber, B. Immune control of HIV: the obstacles of HLA and viral diversity. Nat Immunol 2, 473–475 (2001). https://doi.org/10.1038/88656

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