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Aimez-vous Brahms? A story capriccioso from the discovery of a cytokine family and its regulators

Do you delight in Brahms? Do you delight in immunology? Tada Taniguchi recounts the story of Type 1 interferon and its downstream regulators.

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References

  1. Taniguchi, T., Libonati, M. & Leone, E. Azione della subtilisina sulla ribonucleasi BS-1. Boll. Soc. Ital. Biol. Sper. XLVIII, 1115–1119 (1972).

    Google Scholar 

  2. Flavell, R.A., Sabo, D.L., Bandle, E.F. & Weissmann, C. Site-directed mutagenesis: generation of an extracistronic mutation in bacteriophage Qβ RNA. J. Mol. Biol. 89, 255–272 (1974).

    Article  CAS  PubMed  Google Scholar 

  3. Taniguchi, T., Palmieri, M. & Weissmann, C.Q. β DNA–containing hybrid plasmids giving rise to Qβ phage formation in the bacterial host. Nature 274, 223–228 (1978).

    Article  CAS  PubMed  Google Scholar 

  4. Cavalieri, R.L., Havell, E.A., Vilcek, J. & Pestka, S. Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells. Proc. Natl. Acad. Sci. USA 74, 3287–3291 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Taniguchi, T. et al. Construction and identification of a bacterial plasmid containing the human fibroblast interferon gene sequence. Proc. Jpn. Acad. 55B, 464–469 (1979).

    Article  Google Scholar 

  6. Knight, E., Jr, Hunkapiller, M.W., Korant, B.D., Hardy, R.W. & Hood, L.E. Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence. Science 207, 525–526 (1980).

    Article  CAS  PubMed  Google Scholar 

  7. Nagata, S. et al. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature 284, 316–320 (1980).

    Article  CAS  PubMed  Google Scholar 

  8. Zoon, K.C. et al. Amino terminal sequence of the major component of human lymphoblastoid interferon. Science 207, 527–528 (1980).

    Article  CAS  PubMed  Google Scholar 

  9. Mantei, N. et al. The nucleotide sequence of a cloned human leukocyte interferon cDNA. Gene 10, 1–10 (1980).

    Article  CAS  PubMed  Google Scholar 

  10. Taniguchi, T., Ohno, S., Fujii-Kuriyama, Y. & Muramatsu, M. The nucleotide sequence of human fibroblast interferon cDNA. Gene 10, 11–15 (1980).

    Article  CAS  PubMed  Google Scholar 

  11. Derynck, R. et al. Isolation and structure of a human fibroblast interferon gene. Nature 285, 542–547 (1980).

    Article  CAS  PubMed  Google Scholar 

  12. Taniguchi, T. et al. Human leukocyte and fibroblast interferons are structurally related. Nature 285, 547–549 (1980).

    Article  CAS  PubMed  Google Scholar 

  13. Taniguchi, T. et al. Expression of the human fibroblast interferon gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 77, 5230–5233 (1980).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Morgan, D.A., Ruscetti, F.W. & Gallo, R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193, 1007–1008 (1976).

    Article  CAS  PubMed  Google Scholar 

  15. Taniguchi, T. et al. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302, 305–310 (1983).

    Article  CAS  PubMed  Google Scholar 

  16. Ohno, S. & Taniguchi, T. Inducer-responsive expression of the cloned human interferon β1 gene introduced into cultured mouse cells. Nucleic Acids Res. 10, 967–977 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Honda, K., Takaoka, A. & Taniguchi, T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 25, 349–360 (2006).

    Article  CAS  PubMed  Google Scholar 

  18. Kim, T.K. & Maniatis, T. The mechanism of transcriptional synergy of an in vitro assembled interferon-β enhanceosome. Mol. Cell 1, 119–129 (1997).

    Article  CAS  PubMed  Google Scholar 

  19. Fujita, T., Shibuya, H., Hotta, H., Yamanishi, K. & Taniguchi, T. Interferon-β gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer. Cell 49, 357–367 (1987).

    Article  CAS  PubMed  Google Scholar 

  20. Miyamoto, M. et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. pCell 54, 903–913 (1988).

    CAS  Google Scholar 

  21. Tamura, T., Yanai, H., Savitsky, D. & Taniguchi, T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26, 535–584 (2008).

    Article  CAS  PubMed  Google Scholar 

  22. Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644–658 (2006).

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

I thank J. Vilcek and D. Savitsky for their kind reading of this essay. My particular appreciation goes to my mentor C. Weissmann, from whom I learned so much about science and music (and good jokes), and to the colleagues who spent time in my laboratory through the many facets of the studies described above. I also thank my wife Yoko and my friends, either mentioned herein or not, for their continuous support. Our studies were mostly supported by Kakenhi, Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Finally, I also thank baseball's Hanshin Tigers for their long-standing roller coaster of hope and disappointment, which in addition to music has significantly enriched my life.

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Taniguchi, T. Aimez-vous Brahms? A story capriccioso from the discovery of a cytokine family and its regulators. Nat Immunol 10, 447–449 (2009). https://doi.org/10.1038/ni0509-447

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