How autoreactive thymocytes die remains a question that has not been fully answered. New results supporting a role for the death ligand TRAIL may take us a step closer to unraveling this mystery.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Lamhamedi-Cherradi, S.E. et al. Nat. Immunol. 4, 255–260 (2003).
Simon, A.K. et al. Proc. Natl. Acad. Sci. USA 98, 5158–5163 (2001).
Brunner, T. et al. Nature 373, 441–444 (1995).
Walsh, C.M. et al. Immunity 12, 599–609 (1998).
Smith, K.G. et al. EMBO J. 17, 706–708 (1998).
Bouillet, P. et al. Nature 415, 922–926 (2002).
Anderson, M.S. et al. Science 298, 1395–1401 (2002).
Herr, I. et al. Cell Death Diff. 6, 130–135 (1999).
Yamamoto, K. et al. Mol. Cell. Biol. 19, 8469–8478 (2000).
Rincom, M. et al. J. Exp. Med. 188, 1817–1830 (1998).
Sabapathy, K. et al. Curr. Biol. 9, 116–125 (1999)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Green, D. The suicide in the thymus, a twisted trail. Nat Immunol 4, 207–208 (2003). https://doi.org/10.1038/ni0303-207
Issue Date:
DOI: https://doi.org/10.1038/ni0303-207
This article is cited by
-
Death receptor signal transducers: nodes of coordination in immune signaling networks
Nature Immunology (2009)
-
Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells
Apoptosis (2007)
-
HIV-1 infection and AIDS: consequences for the central nervous system
Cell Death & Differentiation (2005)
-
The signaling and apoptotic effects of TNF-related apoptosis-inducing ligand in HIV-1 associated dementia
Neurotoxicity Research (2005)
-
Following a TRAIL: Update on a ligand and its five receptors
Cell Research (2004)