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Cutting glycolipids down to size

Proteins are digested into peptides for presentation by MHC to T cells. A recent paper in Science reports that some lipids also undergo processing in order to be presented by the unconventional class I protein CD1.

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Figure 1: Extracellular lipids of self or foreign origin are represented schematically with either a single monosaccharide or a small oligosaccharide head-group.

Bob Crimi

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Porcelli, S. Cutting glycolipids down to size. Nat Immunol 2, 191–192 (2001). https://doi.org/10.1038/85234

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