The signaling intermediates that activate inflammasomes are elusive. New data now show that reactive oxygen species causes TXNIP to associate with NLRP3 and activate the inflammasome.
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Davis, B., Ting, JY. NLRP3 has a sweet tooth. Nat Immunol 11, 105–106 (2010). https://doi.org/10.1038/ni0210-105
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DOI: https://doi.org/10.1038/ni0210-105
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