Autoreactive T cells may escape tolerance induction owing to enzymatic cleavage of dominant determinants in the thymus. Processing events both in the thymus and the periphery influence the spectrum of determinants available to T cells.
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References
Manoury, B. et al. Nature Immunol. 3, 169–174 (2002).
Anderton, S. M., Viner, N., Matharu, P., Lowrey, P. & Wraith, D. Nature Immunol. 3, 175–181 (2002).
Sercarz, E. E. et al. Annu. Rev. Immunol. 11, 729–766 (1993).
Watts, C. Annu. Rev. Immunol. 15, 821–850 (1997).
Parham, P. (ed.) Immunol. Rev. 164 (1998).
Antoniou, A. N., Blackwood, S. L., Mazzeo, D. & Watts, C. Immunity 4, 391–398 (2000).
McAdam, S. N. et al. J. Exp. Med. 193, 1239–1246 (2001).
Beck, H. et al. Eur. J. Immunol. 31, 3726–3736 (2001).
Schneider, S. et al. J. Immunol. 165, 20–23 (2000).
Soares, L., Sercarz, E. & Miller, A. Int. Immunol. 6, 785–794 (1994).
Benichou, G. et al. Int. Immunol. 6, 131–138 (1994).
Castellino, F., Zappacosta, F. Coligan, J. E. & Germain, R. N. J. Immunol. 161, 4048–4057 (1998).
Givogri, M. I., Bongarzone, E. R., Schonmann, V. & Campagnoni, A. T. J. Neurosci. Res. 66, 679–690 (2001).
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Sercarz, E. Processing creates the self. Nat Immunol 3, 110–112 (2002). https://doi.org/10.1038/ni0202-110
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DOI: https://doi.org/10.1038/ni0202-110
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