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Lack of fair play in the T cell response

Nature Immunology volume 3, pages 9–10 (2002)Cite this article

Distinguishing which antigen-specific T cell clones will give rise to secondary immune responses is a subject of debate. New data shows higher affinity T cells are better competitors because they are activated more efficiently and can induce the loss of peptide-MHC from DCs.

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Figure 1: Mechanisms of competition among T cells and their effect on T cell responses.

Bob Crimi

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  1. Institute for Research in Biomedicine, Via Vincenzo Vela 6, Bellinzona, 6500, Switzerland

    Antonio Lanzavecchia

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  1. Antonio Lanzavecchia
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Lanzavecchia, A. Lack of fair play in the T cell response. Nat Immunol 3, 9–10 (2002). https://doi.org/10.1038/ni0102-9

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