Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.
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Yáñez, A., Goodridge, H. & Grimes, H. Counting the cost of lineage decisions. Nat Immunol 18, 872–873 (2017). https://doi.org/10.1038/ni.3794
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DOI: https://doi.org/10.1038/ni.3794